Conclusion: The engineered scFv fragment retains the properties of the parent antibody. It shows the inhibition of type ⅳ collagenase and invasion of tumor cells. 结论:运用基因工程手段获得的单链抗体片段保留了亲本抗体的若干特性,对Ⅳ型胶原酶有抑制作用,并能抑制肿瘤细胞的侵袭。
It is suggested that different metastatic potential tumor cells, originating the same parent tumor line, are heterogeneous in their growth speeds, immunogenicity, effects on hosts ′ immunological systems. 表明转移能力不同的瘤细胞,尽管来源于同一亲本Hca瘤株,但其生长速度,对宿主免疫系统的影响、免疫原性也均呈现异质性。